The Hoyas led midway through the second half, but Creighton made a 10-point run to go up by seven with eight minutes left.
Reggie Cameron's dunk drew Georgetown to within three with 6:55 to go. Watson responded with a 3-pointer, and Milliken made a pair from the line to stretch it back to eight.
Georgetown didn't get closer than six points the rest of the way as Creighton ended the game on a 9-2 run.
Creighton made 21 of 25 from the line, while the Hoyas were just 3 of 7.