Once his teammates joined in, Purdue didn't stand a chance.
Uthoff scored 13 of his 22 points in the first half and Iowa toppled No. 22 Purdue 83-71 Sunday for its ninth straight win.
Iowa broke open a tight game with a 23-6 run to start the second half, getting baskets from seven different players during that stretch.
But the Hawkeyes were again keyed by Uthoff, who entered Sunday as the leading scorer and shot blocker in the Big Ten.
''He's a special player. He's one of the best players in the country,'' Iowa point guard Mike Gesell said. ''He can go off at any time.''
Iowa cemented its status as a Big Ten contender with a 70-63 win over Purdue earlier this month, outscoring the Boilermakers 50-26 in the second half in West Lafayette.
The Hawkeyes might have effectively knocked Purdue out of the league race by blowing past the Boilermakers yet again in the second half.
Purdue focused on stopping Uthoff up by two after the break. But Uthoff drew the defense away for a pair of easy layups by Woodbury. Uthoff drove the lane for a left-handed dunk the next time he touched the ball to give Iowa its biggest lead to that point, 47-39.
''That's the beautiful thing about this team,'' Iowa coach Fran McCaffery said. ''That means we're sharing ball.''
The Boilermakers controlled things for much of the first half, though, connecting on six of its first 11 3s. But thanks in part to three well-timed 3s from Uthoff, Iowa stayed within 35-33 at halftime.
''They're a tough team for us to match up against because of their skill and the way they move the ball. They're very unselfish,'' Purdue coach Matt Painter said.
Uthoff and Mike Gesell then opened the second half with 3s to give the Hawkeyes a quick 41-35 lead. That lead would grow to as much as 19 in Iowa's final game before a trip to College Park that could have huge implications for the league race.
Purdue: The Boilermakers were without guard Kendall Stephens, who stayed behind in West Lafayette. Coach Matt Painter said that Stephens, Purdue's sixth-leading scorer at 7.2 points per game, is dealing with the death of a close friend and that Stephens will be given as much time as he needs to heal.
Iowa: The Hawkeyes improved to 7-3 against teams ranked in the top 50 of the RPI...Iowa has won 13 straight at home...The Hawkeyes cruised despite being outrebounded 41-33.
Standout Purdue freshman Caleb Swanigan appeared to tweak his ankle in the first half. He wound up playing 25 minutes but was just 2 of 9 from the floor. Painter said Swanigan's ankle was ''fine'' after the game...The Boilermakers also turned it over 17 times...Peter Jok was 6 of 12 from the floor for Iowa, finishing with 13 points and three steals.
''They get their 3s in a variety of ways. Some off their actions. Some in transition, and then some strictly off matchups. Uthoff gets matchups on bigger people, and then he takes his `horse' shots,'' Painter said, referencing Uthoff's ability to hit difficult jumpers.
Purdue hosts Minnesota on Wednesday.
Iowa plays at Maryland on Thursday.