Stevie Browning led the Thundering Herd (11-10, 7-1 Conference USA) with 15 points. Ryan Taylor had 14 points with six boards, C.J. Burks scored 12 points and James Kelly added 11 points with seven rebounds and four steals.
Quavius Copeland paced the Blue Raiders (14-6, 6-2) with 16 points, while Perrin Buford had 14 points and grabbed nine rebounds. Giddy Potts had 10 points and Reggie Upshaw had 11 boards. MTSU was just 3 of 16 from beyond the arc.
Marshall trailed early, but a 12-2 run midway through the first half - sparked a 3-pointer and dunk by Kelly on consecutive possessions - led to a 37-28 lead at the break.
A 17-6 run by the Herd early in the second pushed the lead over 20 and they cruised from there.