Jeremie Tyler's layup pulled the Cardinals within 56-53 midway through the second half but they didn't score again until Sean Sellers hit a 3 with 1:44 left. Isaiah Johnson had the first five points of Akron's game-breaking 13-0 run and Noah Robotham and Jake Kretzer hit 3-pointers.
Johnson added 13 points on 5-of-7 shooting for the Zips (17-4, 6-2 Mid-American), who made 10 of 24 3-pointers and shot 52 percent overall.
Tyler had 18 points and Bo Calhoun 15 for the Cardinals (13-8, 4-4), who shot 51 percent, including 12 of 25 behind the arc against the NCAA leader that was limiting opponents to 26.1 percent.
McAdams had a layup and 3-pointer on consecutive possessions to start Akron on a 14-4 run that produced a 39-28 lead at the half.