Coach Mark Richt said Sunday Brown tore the anterior cruciate ligament in the knee. The injury will end the senior's college career, but Brown is expected to make a full recovery following surgery.
"We know he'll be able to continue with his pro career because I think he was well on his way to have that happen for him," Richt said.
Brown and another senior, Tavarres King, share the lead with 27 catches. Brown has four touchdown catches.
"I'm very sorry for him and for Georgia, too," Richt said. "It's just a hard thing to swallow right now."
The injury comes one month after another top receiver, Michael Bennett, hurt his right knee in practice, ending his season.
Richt says Rhett McGowan and Justin Scott-Wesley could see more playing time behind King, Malcolm Mitchell, Rantavious Wooten and Chris Conley. King and Brown started against Ole Miss.
"We still have some play-makers," Richt said. "We'll miss him, but other guys will have to step up and get after it."
Richt said offensive guard Chris Burnette, who left the Ole Miss game with a left shoulder injury, is day to day.