Causey went 14 of 22 for 224 yards and rushed for 88 yards, pacing the Tigers over their Southwestern Athletic Conference foe.
Texas Southern went up 17-14 with 6:33 in the first half on Causey's 44-yard touchdown pass to Malik Cross. Prairie View answered with a 76-yard touchdown pass from Jerry Locklove to Nick Petre on the next play. TSU's Eric Medina hit a 30-yard field goal with 2 seconds before halftime to make it 21-20 at intermission.
The Tigers scored 10 third-quarter points, on Causey's 4-yard touchdown run and Medina's 20-yard field goal.
Prairie View cut its deficit to 2 with 2:49 in the game on a 25-yard touchdown reception by Gabe Dunlap, but Texas Southern ran out the clock.