Poppy Livers had five receptions for 110 yards and two touchdowns for the Wildcats (1-1).
Villanova's offense scored touchdowns on three consecutive drives in the second quarter to break the game open, highlighted by Livers touchdown catches of 9 and 21 yards. Austin Calitro also had a 35-yard interception return for a touchdown in the quarter.
Fordham's Michael Nebrich completed 14 of 28 passes for 182 yards.
Michael Marando connected on field goals of 31 and 38 yards for the Rams (1-1), who were outgained 514-219, at one point surrendering 33 consecutive points.
The game was delayed for an hour and nine minutes in the second quarter because of inclement weather.