Daniel Lasco added a 50-yard scoring run as the Golden Bears (2-0) raced to a 42-0 lead midway through the second quarter then coasted to its most lopsided win since beating Presbyterian 63-12 in 2011.
It's the first time Cal has opened with back-to-back victories since winning its first three games in 2011. The Bears went 1-11 last year in coach Sonny Dykes' first season.
Cal also got a lift from its defense, which held Sacramento State (1-1) to minus-12 yards rushing in the first half.
Lasco had a career-high 94 yards on nine carries and provided the signature play of the game with his long touchdown run in the second quarter. He took a handoff from Goff and broke through the left side of the line, did a 360-degree spin at the 45, then outraced three defenders over the final 20 yards to finish the second-longest touchdown run of his career.
Cal scored on its first seven drives before missing a field goal attempt to end the first half.
Goff, the Bears' sophomore quarterback, had scoring throws of 4, 16 and 19 yards, giving him seven touchdowns in what has amounted to be a part-time role.
For the second straight game, Cal used both Goff and Rubenzer, a freshman who led the Bears in rushing during their season-opening win over Northwestern, despite only taking a handful of snaps.
This time it was much different, raising the specter of a potential quarterback controversy.
Rubenzer ran for 34 yards against the Hornets and scored on a 1-yard keeper around the right side. He was equally effective in the pocket, completing 3 of 4 throws for 84 yards, including a 60-yard touchdown to Powe in the first quarter. Rubenzer had a second touchdown pass negated by an offensive pass interference penalty.
James Langford added field goals of 33 and 47 yards for Cal.
Safron, who passed for five touchdowns in Sac State's season-opening win, later scored on a 73-yard run - the longest by any Hornets' player since 2004.