Abdul-Saboor had 107 yards on 18 carries for the Tribe (1-1), scoring touchdowns from short range in the first, third and fourth quarters. Kendell Anderson scored two touchdowns and ran for 34 yards on eight carries.
Steve Culley completed 9 of 16 passes for 135 yards.
The Tribe led 20-0 at the break and never looked back. Leading 27-14 at the end of the third quarter, William & Mary would score twice more in the fourth on goal-line runs by Abdul-Saboor and Anderson.
Hampton's first score of the game came on a 54-yard run by Christopher Dukes early in the third quarter. Five minutes later, Jaylian Williamson completed a 50-yard pass to Jorrian Washington for the second and final Hampton touchdown.
Williamson finished the day with 335 yards passing for the Pirates (0-2).