Williams totaled 62 yards rushing, Jeremiaha Games ran for 63 yards and a touchdown, and Robert Clark had two carries for 48 yards and a score and caught four passes for 68 yards to help the Bulldogs (1-1) win their home opener.
Williams' third scoring touchdown, a 15-yard run, made it 28-0 with 11:42 to go in the second quarter.
Samford finished with 492 yards of total offense, including 294 yards rushing. Quarterback Michael Eubank was 15 for 23 passing for 131 yards and a touchdown, and also had 50 yards rushing.
Stillman (0-2) was limited to 185 yards of total offense - including just 20 yards passing.