Midway through the first quarter, Defensive back JeMar Marshall recovered a fumble by Southern quarterback Deonte Shorts and ran the ball in 9 yards for a touchdown, giving Northwestern State (1-2) a 17-0 lead.
Adkins threw two more touchdowns in the second quarter to build a 34-7 lead by halftime.
Shorts was 13 of 21, threw one touchdown and ran for another score for Southern (1-2). Austin Howard also played quarterback and threw a 79-yard touchdown pass to Willie Quinn, but Howard also threw three interceptions. Quinn had 107 receiving yards, and Justin Morgan had 109 receiving yards and a touchdown.
Nine different receivers caught passes for Northwestern State, led by Cody Jones with 6 catches for 43 yards.