Coach Dana Holgorsen announced the sophomore's suspension Monday night without elaborating.
Worley has started all three games for West Virginia (2-1), which hosts No. 4 Oklahoma (3-0) in their Big 12 opener on Saturday night.
Worley has 17 total tackles and two interceptions this season.
Junior Ricky Rumph is listed as Worley's backup. Rumph has yet to make a start in 21 career games.