The Gamecocks (2-1) had three different quarterbacks combine to go 17 of 29 for 294 yards and four touchdowns. Max Shortell threw two scores to Barge and Eli Jenkins had an 88-yard strike to Markis Merrill.
Leading 24-14 at halftime, Jacksonville State pulled away as Barge caught touchdowns of 13 yards from Shortell and 14 yards from Christian LeMay. Jermaine Hough added a 34-yard interception return for a score in the fourth quarter to make it 45-14.
Kyle Caldwell led a string of late scoring drives, but West Alabama still trailed by 11 and couldn't recover the ensuing onside kick. Caldwell threw for 356 yards with four touchdowns and an interception.