Youngstown State (4-1, 1-0 Missouri Valley Football Conference) struck first as Dante Nania threw an 8-yard touchdown pass to Andrew Williams early in the first. Webb's long TD run in the second quarter put the Penguins up 14-0.
Youngstown State stopped Missouri State on fourth-and-goal at the 6 with 10:34 left in the game. On the ensuing possession, Missouri State (3-2, 0-1) blocked a punt that was recovered at the Youngstown State 14. Eight plays later, Kierra Harris connecting with Gannon Sinclair for a 4-yard touchdown.
Nania completed 10 of 16 passes for 130 yards with one interception for Youngstown State. Tre' Moore led the Penguins defense with two interceptions of Harris.