Whitlow connected with Adam Drake with a 50-yard strike in the first quarter, and hit Drake again with a 5-yard touchdown late in the third. Whitlow ran for 3, 13, and 2-yard scores. He finished with 213 yards passing without an interception, and ran for 75.
Deonte Jackson recovered a fumble, Jourdan Wickliffe had two interceptions, and Anthony Goodman and Anthony Standifer had one. Jimmy Lera added a 96-yard touchdown run midway through the fourth for Eastern Illinois (2-5, 2-1 Ohio Valley).
Eastern Illinois bounced back after having its 13-game conference win streak snapped last week against Eastern Kentucky.
Kyle Snyder threw for 210 yards with one touchdown and three interceptions for Southeast Missouri (4-4, 2-2).