Mobley ran for 111 yards on 27 carries, and EKU went over 30 points for the sixth straight game. Devin Borders added 106 yards receiving and a score.
The Colonels (7-1, 4-1 Ohio Valley) scored first when Jeff Glover blocked and returned a punt 22 yards in the first quarter. Mobley gave EKU the lead for good at 14-7 with a 1-yard touchdown near the end of the quarter. He scored again in the second quarter.
Snyder passed for a touchdown and rushed for 116 yards and two scores.
The Colonels increased their series edge to 22-3, including 10 wins in the last 11 meetings.