USC coach Steve Sarkisian disclosed the extent of Wheeler's injury Sunday.
Sarkisian says Wheeler tore the ACL in his knee on the third play of USC's 24-21 loss to Utah on Saturday night, but stayed in the game for several more plays.
Wheeler is a 6-foot-7 redshirt sophomore from Santa Monica who has started all 22 games for USC (5-3, 4-2 Pac-12) over the past two seasons. He won the starting job on the thin offensive line and emerged as a leader this fall.
Aundrey Walker took over at left tackle. He will remain at the spot this week, Sarkisian says.