McClain finished with 139 yards on 23 carries and also threw for 70 yards on 10-of-18 passing. His 36-yard touchdown run put the Colonels (8-1, 5-1 Ohio Valley) in the lead for good, 27-21. He added a 2-yard rushing score and an 8-yard touchdown pass to Jeff Glover to make it 49-28 with 5:40 remaining.
Mobley rushed 27 times for 139 yards with three touchdowns. His first two scores helped Eastern Kentucky grab an early 17-0 lead.
Michael German threw for 326 yards with four touchdowns and a rushing score for Tennessee State (4-6, 1-5). German's 5-yard touchdown to Quindell Cousins pulled the Tigers within 7 late in the third, but his second interception led to Glover's TD reception.
Ryan Mitchell had 119 yards receiving for the Tigers.