Chattanooga (8-3) allowed Tennessee Tech just nine first downs and 171 total yards, 64 of which came on a touchdown run by Ladari Vanlier, and held the ball for 40 minutes.
Vanlier's touchdown pulled Tennessee Tech (4-7) within four midway through the second quarter, but Chattanooga responded with an 8-play, 60-yard drive capped by a 2-yard scoring pass from Huesman to Taharin Tyson about 2 1/2 minutes left in the half.
On the first play of the ensuing drive, Keionta Davis strip-sacked Darian Stone and recovered the fumble, setting up a 9-yard touchdown catch by Tommy Hudson, giving Chattanooga a 28-10 lead at halftime.
Tennessee Tech never threatened again.
Huesman's 7,705 career yards of total offense ranks 5th in Southern Conference history.