Fleming found four different Florida A&M receivers for a touchdown. He hit Montavius Williams with a 40-yard pass to bring the score to 14-0, then found Zachary Webster and Brandon Norwood - for 10 and 11 yards, respectively - and the Rattlers (3-8, 3-4 Mid-Eastern Athletic) held a 31-0 lead at the break.
Quarterback Marlon Kelly found the end zone on a 2-yard run with 3:13 left in the third quarter to avoid the shutout for Delaware State (2-9, 2-5).
Desmond Noird had a 17-yard touchdown reception from Fleming to cap a 10-play, 61-yard drive for the final score of the game.
Kelly finished with 204-yards passing, and Malik Golson had 121 yards on 14 carries for the Hornets.