JoJo Natson ran for a career-high 124 yards and a touchdown for the Aggies (9-3, 6-1 Mountain West). Utah State totaled a season-high 313 yards rushing to 191 for the Spartans (3-8, 2-5).
San Jose State's starting quarterback Blake Zurich was injured when Zach Vigil sacked him for a 10-yard loss on the first play of the game. He never returned.
Myers' 60-yard touchdown run in the second quarter was the second-longest run of the season for the Aggies.
Natson's second-half touchdown run of 56 yards, on the first play of the half, was his seventh score of the season.