The Rattlers (0-2) led 14-10 at the end of the first quarter when Gerald Hearns scored from a yard out. FAMU's Akil Blount earlier intercepted Eubank and ran 65 yards to score to put the Rattlers up 7-3.
But Samford (2-0) broke the game open in the second. Eubank completed an eight-yard score to Tony Philpot for a 17-14 lead with 13:23 until half. K'rondis Larry ran 10 yards for a score seven minutes later to make it 24-14.
Eubank carried the ball six yards to score for a 31-14 lead. Then Justin Cooper intercepted Carson Royal and scored from 13 yards out to make it 38-14. Anthony Pistelli made a 27-yard field goal to make it 41-14 at the half.
Devin Bowers had 144 yards rushing for FAMU.
AP College Football website: www.collegefootball.ap.org