The Bobcats (1-1) jumped ahead with five TDs in the first quarter capped by Brandon McDowell's 95-yard punt return to make it 35-3 as the period expired.
De'Auntre Smiley scored the Panthers' first touchdown with a 4-yard run early in the second quarter, but Texas State answered with three straight TDs, extending their lead to 56-10. Prairie View (1-1) scored another touchdown before the half.
Robert Lowe ran for 104 yards and Chris Nutall added 92 - each with two TD runs. Brandon Smith caught two passes for 99 yards and a touchdown, and Jafus Gaines had four receptions for 92 yards and a score.
Trey Green led the Panthers with 25-of-37 passing for 289 yards and two touchdowns.
AP College Football website: www.collegefootball.ap.org