Lee was 15 of 26 for 190 yards and backup Devin Powell also threw for a score. Five different Green Wave receivers caught touchdown passes.
Tulane (2-2, 1-0) took advantage of three interceptions and two fumbles, scoring 28 points off turnovers, and held the Knights (0-5, 0-1) to minus-35 yards rushing.
Two-time defending conference champion UCF has been hit hard by injuries this season, particularly on offense. Freshman Bo Schneider threw for 236 yards and a score but had three picks. Another freshman, Tyler Harris, came in and threw three fourth-quarter touchdowns, all to freshman D'erren Wilson.