Drayer was 16 of 28 for 292 yards. Khairi Dickson had 161 yards rushing and a touchdown, Marcus Bagley added 126 yards and a score, and Terell Smith had six catches for 130 yards. Failace's three touchdown receptions covered just 23 yards.
The Red Flash (3-2, 1-0 Northeast) scored 27 points in the second half after leading 16-7 at intermission.
It was a two-score game at the end of the third after Wagner's Najee Harris blocked a punt and returned it 13 yards for a touchdown. But St. Francis scored the next 17 points, including Drayer's 8-yard scoring pass to Failace and Bagley's 5-yard touchdown run.
Alex Thomson was 12 of 25 for 111 yards and a 15-yard touchdown pass to Lloyd Smith for Wagner (0-6, 0-2).