Knighten found a wide open Darion Griswold in the end zone for a 20-0 lead and completed a deep ball to Chris Murray for a 46-yard touchdown to make it 34-7.
Louisiana-Lafayette rallied in the second half. Elijah McGuire out-jumped a defender for a 20-yard touchdown with 11:02 remaining in the fourth quarter, but he was stopped on a 2-point conversion attempt to keep it a two-possession game at 37-27.
Jalen Nixon passed for 253 yards, rushed 201 yards, and had three touchdowns for Louisiana-Lafayette (2-4, 1-1). McGuire had a career-high 134 yards receiving and a touchdown.