York's first score to Dondre Brown gave the Bulldogs a 20-0 lead midway through the second quarter. He found Lynard Jamison for 68 yards on the second play of the third quarter to push the lead to 27.
York was 17 of 28 for 241 yards and an interception for South Carolina State (4-3, 3-1 Mid-Eastern Athletic Conference) before giving way to Adrian Kollock. Brown and Jalen Simmons each rushed for scores. Brown had 51 yards on six carries.
The Hornets have lost 12 straight dating back to last season.