Whitlow threw a 16-yard scoring pass to James Brooks late in the second quarter to help Eastern Illinois to a 17-10 halftime lead.
Devin Church ran for a touchdown early in the second half and Little scored on a 12-yard run, stretching the Panthers' lead to 31-13 with a minute left in the third quarter.
In the fourth quarter, Jarvis Williams scored on a 24-yard interception return and backup QB Austin Green hit Paul Gossage from 33 yards to make it 44-13. Harrison's 83-yard touchdown run with 2:40 to play sealed the win.
Colby Brown had 115 yards passing for the Golden Eagles (2-6, 1-4).