Coach: James Madison quarterback Lee out 'indefinitely'
The school said in a release Lee will have an MRI on his foot and be evaluated on a week-to-week basis.
Lee is considered among the front-runners for the Walter Payton Award given to the top FCS player.
He had run for three touchdowns and thrown for two before being sidelined against the Spiders. In a 48-45 victory at SMU in September, Lee ran for 276 yards and two touchdowns, passed for 289 yards and three scores, including a game-winning 17-yard touchdown with 27 seconds remaining.