The Panthers (5-3, 4-0 Ohio Valley Conference) have won five consecutive games following a three game losing skid to open the season.
Jalen Whitlow added 236 yards passing and one touchdown for the Eastern Illinois, an 80-yard strike to Ben Odugbesan in the third quarter. Tray Mitchell also returned a kick 94 yards for a TD for the first Panthers points of the game.
Eastern Illinois took the lead for good 26 seconds into the second quarter on a 1-yard Little TD run.
Humphries had 346 yards passing and two touchdowns for the Racers.