York was 14 of 26 for 172 yards passing and Taquan West caught two touchdown passes for South Carolina State (5-3, 4-1 Mid-Eastern Athletic Conference), which has won three straight.
Jerrell Antoine was 17-of-32 passing for 223 yards with two fourth quarter touchdown passes to lead Hampton (4-5, 3-3). He also caught a 19-yard touchdown pass from Twarn Mixon.
York had scoring throws of 20 and 39 yards to West in the first half, and a 9-yard touchdown pass to Lynard Jamison to open the third quarter to give the Bulldogs a 21-0 lead.
Antoni Hamilton returned a kickoff 89 yards into the end zone, and Tyler Scandrett kicked a 32-yard field goal to give the Bulldogs a 31-6 lead late in the third quarter.