Vanderbilt coach Derek Mason announced Tuesday that neither player would be available the rest of the season. Mason added that quarterback Kyle Shurmur is ''day to day'' after getting hurt last week in a 34-0 loss to Houston.
Bowden had a team-high 78 tackles as a redshirt freshman last season but has played in only two games this year because of a concussion.
Skule, a true freshman, made two starts at right tackle this season.
Mason added that defensive end Caleb Azubike is expected to play this week after missing Vanderbilt's last three games.
Vanderbilt (3-5, 1-3 SEC) plays at No. 11 Florida (7-1, 5-1) on Saturday.
AP College Football website: www.collegefootball.ap.org