The Panthers took advantage Indiana State's three turnovers to score 28 straight in the second quarter.
Bailey scored his second 1-yard TD run to make it 17-0 with 11:56 left in the second quarter. Tim Kilfoy returned an interception 30 yards for a touchdown a minute later. Another interception led to Michael Malloy's 10-yard score and Bailey followed a Sycamores fumble with a 2-yard TD run to make it 38-0 before the break.
Robert Tonyan Jr. had three catches for 80 yards and a touchdown for Indiana State (4-5, 2-4).