Punter Wil Lutz, who missed two field-goal attempts, tried to pass on fourth-and-5 from the Georgia State 24, but the ball was caught by defensive end Tevin Jones for a loss. The Ragin' Cajuns (4-4, 3-1 Sun Belt) declined the illegal touching penalty and reached the Panthers 5 before Artigue's field goal with 6:59 remaining.
Savion Brown's interception ended a final drive for Georgia State (2-6, 1-3) with 1:58 left.
Artigue kicked a career-long 49-yarder with 1:30 left in the third to get the Ragin' Cajuns within 21-20.
Al Riles had 103 yards receiving with a TD for Louisiana-Lafayette.