The Mustangs (3-6, 2-4 Big Sky) rushed for 366 yards on 60 carries. Reagan Enger led the way with 91 yards on six carries, including a 70-yard run for a touchdown that pushed the Cal Poly lead to 36-7 with 5:19 left to play.
Nate Ketteringham completed 33 of 42 for 335 yards and a touchdown to lead Sacramento State (2-7, 1-5). Shane Harrison caught 12 passes, including the touchdown throw with 1:43 left, for 128 yards. Jaelin Ratliff caught 9 passes for 116 yards.
Sacramento State opened the game with an 11-play drive to the Cal Poly 15, but Brad Cornish's 32-yard field goal attempt was blocked.