David Cutcliffe said Thursday that Sirk suffered an unspecified upper-body injury during last week's loss at North Carolina.
Sirk is third in the Atlantic Coast Conference in total offense, averaging nearly 282 total yards, and is the league's No. 10 rusher with an average of 61.7 yards.
If he can't play, redshirt sophomore Parker Boehme will earn the start. Boehme is 11 of 15 this season for 153 yards and a touchdown, and also has rushed for three scores.