Neal found Caylon Weathers from 10-yards out in the third quarter and, less than four minutes later, connected with Rod Wright for the second time, this one from 20-yards out to give the Skyhawks (7-4, 6-2 Ohio Valley) a 28-10 lead.
Neal finished 16 of 29 for 164 yards, but was picked off once. The Skyhawks rushed for 247 yards on 41 carries.
Vandeven completed 21 of 39 for 226 yards and two touchdowns for Southeast Missouri State (4-7, 3-4), but was picked off three times. Tremane McCullough ran for 101 yards and a score.