Knighten finished 23 of 42 for 367 as the Red Wolves ran up 605 yards of offense.
New Mexico State (3-8, 3-4 Sun Belt) started the scoring, taking the opening possession 75 yards on seven plays, the final 46 of which came on Andrew Allen's touchdown pass to Jordan Bergstrom. It was all Arkansas State (8-3, 7-0) from there.
Knighten hooked up with Dijon Paschal for a 75-yard touchdown pass, and then ran for a 5-yard score following an 18-play drive. Johnston White made it 21-7 at the end of the first with an 18-yard scoring jaunt.
Allen hit Bergstrom for another score, a 12-yard play, but the Red Wolves went right back to work, with Michael Gordon scoring on a 2-yard run and Blaise Taylor's 73-yard punt return for a touchdown, which made it 35-14 at halftime. Taylor also had an interception.