Despite being suspended for two games last season, the junior had 33 tackles and was tied for second on the Hoosiers with four sacks. He also had his first career interception in Saturday's Pinstripe Bowl.
Latham is the second Indiana player this week to leave early. Running back Jordan Howard made his announcement Monday. A year ago, running back Tevin Coleman also gave up his final year of eligibility to enter the draft.
Latham, an Indianapolis native, finishes his college career with 81 tackles, 7 1/2 sacks, 18 1/2 tackles for loss, two fumble recoveries, one interception and two blocked kicks.