The Big 12 rushing champion is the second Mountaineer player to announce he's leaving school early, joining defensive back Daryl Worley.
Smallwood finished with 1,519 rushing yards this season as West Virginia went 8-5 and beat Arizona State 43-42 in the Cactus Bowl. It was the fourth-most yards in a season in West Virginia history and doubled Smallwood's production of a year ago.
Smallwood said in a statement Wednesday night that he believes ''the time is now'' to pursue his dream of an NFL career.
The junior was voted to The Associated Press all-Big 12 second-team.