Week 3 is a huge one in college football, with multiple big-time matchups. Ohio State and Alabama are among the favorites as we take an early look at the odds.

By OddsShark
September 12, 2016

The Ohio State Buckeyes are 13–1 straight up and 10–4 against the spread in their last 14 games played in the month of September. To keep that trend of success going, the Buckeyes will need to win on the road this Saturday against the Oklahoma Sooners.

No. 3 Ohio State is a 2-point road favorite in Norman at sportsbooks monitored by OddsShark.com. Since ending the 2015 regular season on a 7–0 SU and 6–1 ATS run, No. 14 Oklahoma is just 1–2 SU and 0–3 ATS over its last three games. The Sooners are 7–0 SU and 4–3 ATS in their last seven games at home.

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Two ACC powerhouses clash on Saturday when the Florida State Seminoles visit the Louisville Cardinals. No. 10 Louisville has been good at exacting revenge in recent years, with a 12–2 SU record in its last 14 games against an opponent it lost to in the previous matchup. No. 2 Florida State defeated Louisville 41–21 at home last season, and the Cardinals will try to return the favor in Louisville on Saturday. The Cardinals are 2.5-point home underdogs.

The Ole Miss Rebels are 2–0 SU and ATS in their last two games against the Alabama Crimson Tide, pulling off two straight upsets against the defending champions. No. 19 Ole Miss will once again be the underdog on Saturday, hosting No. 1 Alabama as a 10-point dog.

Since their last loss to Ole Miss in Week 3 of the 2015 season, the Tide are 14–0 SU and 9–5 ATS, per the OddsShark College Football Database.

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Rounding out the games played between two ranked teams this week, No. 12 Michigan State is a 7.5-point underdog on the road against the Notre Dame Fighting Irish. No. 18 Notre Dame has turned the tide in this rivalry with a 4–1 SU and 3–1–1 ATS record in its last five games against the Spartans. In the previous 12 games between these two teams, Michigan State was 9–3 SU and 9–2–1 ATS against the Irish.

Other top matchups on the board include No. 22 Oregon at Nebraska (–3), No. 17 Texas A&M at Auburn (–3.5) and USC at No. 7 Stanford (–8.5). Oregon is 8–0 ATS in its last eight games on the road.

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