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College football Week 12 odds: Betting odds for the biggest games

A pair of teams that recently saw their perfect seasons come to an end will try to play spoilers against unbeaten conference opponents this Saturday in the two biggest college football betting matchups of Week 12.

A pair of teams that recently saw their perfect seasons come to an end will try to play spoilers against unbeaten conference opponents this Saturday in the two biggest college football betting matchups of Week 12.

The 10th-ranked Baylor Bears (8–1) lost 44-34 at home to the seventh-ranked Oklahoma Sooners (9–1) last week and hope to pull off the upset when they visit the fourth-ranked Oklahoma State Cowboys (10–0) as one-point road underdogs at sportsbooks monitored by OddsShark.com in an important Big 12 matchup.

The favored team is 12–4 against the spread in the past 16 meetings, with Baylor going 3–16 straight-up in the last 19.

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The Sooners also have another huge conference game this week when they host the 11th-ranked TCU Horned Frogs (9–1). However, there is currently no line on that Big 12 game because TCU quarterback Trevone Boykin (ankle) and wide receiver Josh Doctson (wrist) are both considered questionable due to injuries.

Oklahoma is 14–0 SU in its last 14 games after winning as an underdog but just 2–5 ATS in the past five meetings with the Horned Frogs, according to the OddsShark College Football Database.

There are a couple key games in the Big Ten as well, none bigger this week though than the third-ranked Ohio State Buckeyes (10–0) hosting the 13th-ranked Michigan State Spartans (9–1).

The defending national champion Buckeyes are listed as 13-point home favorites against the Spartans, who lost their first game two weeks ago on the road 39–38 to the Nebraska Cornhuskers.

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Michigan State quarterback Connor Cook left last week’s 24–7 home win over the Maryland Terrapins after taking a hard hit in the first half and hopes to play to help the visiting team improve upon a 6–1 ATS mark in the last seven games between the schools. Ohio State is 9–2 SU in the past 11 meetings.

The other Big Ten battle between ranked teams will happen in Madison on Saturday when the 25th-ranked Wisconsin Badgers (8–2) host the 18th-ranked Northwestern Wildcats (8–2).

Both trail the fifth-ranked Iowa Hawkeyes (10–0) in the Big Ten West, with Wisconsin sitting as an 11-point home favorite. The Hawkeyes are 21-point home chalk against the Purdue Boilermakers (2–8) and close out the regular season at Nebraska.