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College football Week 4 odds: Betting lines for biggest matchups

Michigan State and Texas A&M enter week 4 as heavy favorites. 

The Michigan State Spartans are 4-0 straight up and 3-0-1 against the spread in their last four games against Big Ten opponents. The Spartans can extend that winning streak to five this Saturday in their first conference game of the season hosting the Wisconsin Badgers.

No. 8 Michigan State is a 6-point favorite at home against No. 11 Wisconsin at sportsbooks monitored by Wisconsin has won each of its last seven games on the road, but hasn't historically enjoyed success on the road against Michigan State with an 0-4 SU and 1-3 ATS road record against the Spartans since 2004.

AT&T Stadium in Arlington will play host to another matchup between two undefeated ranked teams as the No. 10 Texas A&M Aggies take on the No. 17 Arkansas Razorbacks. Texas A&M is listed as a 6-point betting favorite.

Arkansas is 0-4 SU and 2-2 ATS in its last four games against the Aggies. To make matters worse for the Razorbacks, the team is 0-10 SU in its last 10 games against opponents that it lost to in the previous game of a matchup. Texas A&M defeated Arkansas 28-21 in Arkansas last season.

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Texas A&M vs. Arkansas is one of three games in Week 4 between ranked SEC opponents. The others are No. 12 Georgia at No. 23 Ole Miss and No. 19 Florida at No. 14 Tennessee.

Ole Miss is 7-2 SU and 6-3 ATS at home since the start of the 2015 season and is a 7-point favorite on Saturday. The Rebels have already lost two games this season, but still remain in the Top 25 coming off a solid effort in a 48-43 loss against the Alabama Crimson Tide. Georgia has won each of the last 10 meetings between these two teams.

Florida has a similar winning streak over Tennessee, winning each of its last 11 games against the Volunteers. And like the Bulldogs, the Gators are not favored to extend that win streak going off as a 7-point underdog.

Tennessee is 6-0 SU in its last six games at home, but just 1-5 ATS in its last six games in Week 4 per the OddsShark College Football Database.