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College football Week 11 odds: Betting lines for biggest matchups

Washington-USC headlines the Week 11 college football slate, with the Huskies the clear favorite. Here's a look at the early odds for all of Saturday's biggest games.

The Washington Huskies are 8–0 straight up and 5–3 against the spread in their last eight games against Pac-12 opponents. The Huskies hope to keep this trend of success alive on Saturday at home against the USC Trojans.

Washington is an 8-point home favorite at sportsbooks monitored by With the Pac-12 suffering through a down year with usual powerhouses like Oregon and Stanford struggling, the undefeated Huskies don't have many more chances left on their schedule to make a statement. This game and a road contest in the final week of the regular season against Washington State could help the Huskies make their case to the playoff committee.

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USC is 1–5 SU and 0–6 ATS in its last six games coming off a win in its previous road game.

In both 2014 and 2015, the LSU Tigers followed up losses to Alabama with 17-point losses to the Arkansas Razorbacks. The Tigers are hoping to make sure that history does not repeat itself this Saturday as 7-point road favorites against the Razorbacks.

LSU was 3–0 SU and ATS under interim coach Ed Orgeron before running into Alabama's elite defense in a 10–0 loss at home last week. Arkansas is 8-1 ATS in its last nine games against the Tigers.

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After slogging through a 3–1 SU and 0–4 ATS slump that included an outright loss to Penn State as 17.5-point favorites, the Ohio State Buckeyes got back on track with authority last Saturday in a 62–3 win at home over the Nebraska Cornhuskers. Ohio State still controls its own destiny in the Big Ten and is a 28.5-point road favorite this week against the Maryland Terrapins.

The Buckeyes are 9–0 SU and 7–2 ATS in their last nine road games after playing consecutive games at home per the OddsShark College Football Database.

Ohio State moves into the top five of Power Rankings after Week 10

The other undefeated teams in action this Saturday are Michigan as a 21-point road favorite at Iowa, Clemson as a 20.5-point favorite at home against Pittsburgh and Alabama as a 29-point favorite at home against Mississippi State.

Alabama has won each of its last eight games against Mississippi State and each of its last nine games played in the month of November.