Fredrik Norrena appeared to make the initial save on Comrie's low shot, but the puck trickled between his pads for the lone goal of the shootout. Mikael Tellqvist made 21 saves in regulation and stopped all three shootout attempts for the Coyotes, who snapped a three-game losing streak.
Comrie and Ed Jovanovski each had a goal and an assist, and Owen Nolan and Derek Morris also scored for the Coyotes, 3-0 in shootouts this season.
Rick Nash had a goal and two assists for the Blue Jackets. Sergei Fedorov, Anson Carter and David Vyborny also scored for Columbus, which had its five-game winning streak snapped.