Street has been hampered by inflammation this spring and has yet to throw in an exhibition game. He threw about 25 pitches Monday and said afterward that his arm "felt great" but had discomfort during his throwing session the next day.
"He should be fine," said GM Dan O'Dowd. But the Rockies plan to "take it slow" with him.
Street signed a three-year $22.5 million deal in January after saving 35 of 37 games for the Rockies last season.
If he's not ready for Opening Day, Franklin Morales and Manny Corpas would be the likely candidates to step in for Street.
In the meantime, the Rockies are looking for an extra reliever, with free agent left-hander Joe Beimel a possibility.