Sandoval took an odd swing at Chris Sale's 0-2 inside fastball and the pitch hit him on the arm Thursday night. As Sandoval doubled over in pain, umpire Bill Miller called Sandoval out to end the fourth inning because he swung.
It was the second straight night Sandoval left a game early. He departed in the fifth inning Wednesday night with what the team called dehydration.
Josh Rutledge replaced Sandoval at third.