The first time the 49ers faced the Rams, Kaepernick entered in relief of Alex Smith. He was held in check in the passing game (11-of-17 for 117 yards), but ran wild on the ground (eight carries, 66 yards, one touchdown). Taking first team reps in practice for the third straight week will make a big difference in his passing numbers against a defense that let Arizona's Ryan Lindley throw for 312 yards last week.
2 of 14Sam Greenwood/Getty Images
Every quarterback to start a game against the Bills this season has thrown for at least one touchdown. Given how Henne has clicked with his much-improved receiving corps of Justin Blackmon, Marcedes Lewis and Cecil Shorts (seven touchdowns over the past nine quarters), that streak will continue Sunday in Orchard Park.
3 of 14Sam Greenwood/Getty Images
The Jalen Parmele era lasted just one game, as a groin injury forced the special teams maven to injured reserve. With Maurice Jones-Drew's return nowhere on the horizon, Montell Owens and newly signed ex-Vikings practice squad man Jordan Todman are Jennings' lone safety nets this week in Buffalo. Only the Saints have surrendered more fantasy points to opposing running backs than the Bills, who have given up 14 rushing touchdowns in 11games.
4 of 14Elsa/Getty Images
On Monday Brown sliced up the Panthers for 178 yards and two touchdowns on 19 carries, the fifth time this season an Eagles lead back has rushed at least 19 times. Philly's offensive line is still a problem, but Dallas' loss of starting inside linebacker Bruce Carter to injured reserve should be enough to insure another good day from Brown.
5 of 14Ric Tapia/Icon SMI
The former Oregon Ducks star has yet to see any NFL action after being selected in the second round of the 2012 draft, but with a season-ending Achilles injury to Kendall Hunter, Jim Harbaugh's squad needs someone else to step up in the backfield. James' 5-foot-8 frame and explosiveness makes him perfectly suited for the "Darren Sproles" role that has become so popular around the league. Although he's a long shot to be a big producer, look for James to get some touches this week against the Rams in what could quickly become a new-look 49ers attack.
6 of 14David Bergman/SI
Ready or not, the disappointing rookie has been thrust into the role of Ahmad Bradshaw's backup following Andre Brown's season-ending broken leg. Chances are, Wilson won't be asked to score along the goal line like Brown (eight touchdowns), but even against a Redskins defense that has faced the fewest rushing attempts in the league, Wilson should see enough action in relief of the oft-injured Bradshaw to fill a desperation flex role.
7 of 14Damian Strohmeyer/SI
He has only 10 catches all season, but five came two games ago once his second-team partner Nick Foles took over at quarterback. With DeSean Jackson gone for the year, Cooper and Foles will get more chances to show off their chemistry. Standing at 6-foot-3, Cooper could be a tricky cover for Dallas' smaller corners.
8 of 14MSA/Icon SMI
Titus Young has returned to practice for the Lions, but that shouldn't have much of an impact on Broyles, who is an important part of Matthew Stafford's resurgence in the second half. In their last two games away from Lucas Oil Stadium, the Colts have allowed 661 yards and four touchdowns through the air. That bodes well for the reliable possession receiver Broyles has become.
9 of 14Scott Cunningham/Getty Images
Having connected with Chad Henne on at least one 50-plus-yard play in each of the last three games -- two of which went for touchdowns -- Shorts faces a tough test against a Bills team that has allowed just one such pass all season. However, fantasy owners should feel confident that even if Shorts doesn't break a long one off, he'll produce enough to start this week.
10 of 14Marc Serota/Getty Images
Bess has just 12 touchdowns in 75 NFL games over five seasons. But in four of the past five games he has played against the Patriots, he has scored. Coming off of a seven-catch, 129-yard game with Seattle, Miami's No. 2 receiving option is well worth using this week against Belichick's bunch.
11 of 14Patrick Green/Icon SMI
On Thanksgiving he more than doubled his previous career totals with seven catches for 68 yards against the Redskins while filling in for the injured Miles Austin and Kevin Ogletree. While it's likely that Ogletree plays against the Eagles this week, Beasley had enough success (five first downs) to trip a switch in Jason Garrett's mind and carve out a spot for himself in the Cowboys' offense.
12 of 14Streeter Lecka/Getty Images
Do you think Clark would like to have a big game in front of his former quarterback Peyton Manning? The Broncos' defense has been one of the team's strengths this season, except when it comes to defending tight ends. No team has given up more touchdowns (eight) to the position than Denver, and only the Patriots and Redskins surrender more yards.
13 of 14David Bergman/SI
New York lost its red zone machine Andre Brown for the rest of the season and will have to get a bit more creative with its play-calling. Enter Bennett, who scored touchdowns in each of the first three games of the year but hasn't reached the end zone since. He should get back on track facing a defense that has given up the most catches, second-most yards and third-most touchdowns to tight ends this season.
14 of 14Sharon Ellman/AP
No kicker is hotter than Dawson, who tied for the league lead in points per game during November (10.3) after making all nine of his field-goal attempts. He faces a Raiders squad that has allowed double-digit scoring to kickers seven times in 11 contests this season and has given up an average of 42.3 points per game for the month, including four straight games of 34 or more.
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