Pierce had started Baltimore's past two games, filling in for Ray Rice, who was released by the team and suspended indefinitely by the NFL this month for domestic violence.
Pierce will be replaced by Justin Forsett, who has averaged 6.6 yards on 19 carries and scored a touchdown through two games.
The Browns get back one of their top offensive players, Pro Bowl tight end Jordan Cameron. He returns after sitting out last week with an injured right shoulder. Cameron first was hurt in training camp and aggravated it in the season opener. He was limited in practice this week. Cameron had 80 catches for 917 yards last season.
Also, Browns linebacker Barkevious Mingo returns after missing last week with a shoulder injury.
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