Rose got treatment before Friday night's matchup with the New York Knicks and was considered a game-time decision. But the Bulls announced shortly before tipoff that Kirk Hinrich would start instead of Rose.
Rose also missed Wednesday night's 102-100 overtime win against Indiana. The 2011 NBA MVP is averaging 14.4 points in 27 games this season.
Chicago center Joakim Noah missed his fifth straight game with a left shoulder sprain. Bulls coach Fred Hoiberg said Noah is doing well and will be re-evaluated on Monday.